Britain's Prime Minister Theresa May shakes hands with President Trump before a black-tie dinner with business leaders at Blenheim Palace, west of London, Thursday.
But while Trump's Friday morning plans involve a visit to a military site with May, followed by their joint press conference at Chequers, the first lady is expected to remain in London, in the company of May's husband, Philip May.
While she hopes the Trump visit will focus on trade and strengthening security ties, it is likely to be heavy on rhetoric about the transatlantic "special relationship" and short on specifics such as any details of a post-Brexit trade deal.
Speaking at an impromptu press conference after a North Atlantic Treaty Organisation summit in Brussels Trump said the British people shared his concerns on immigration, claiming "that's why Brexit happened".
He added: "I've been reading a lot about Brexit over the last couple of days, and it seems to be turning a little bit differently, where they're getting at least partially involved back with the European Union", Mr Trump said.
On Friday, Mrs May and Mr Trump will go to watch a joint counter-terrorism exercise by British and USA special forces at a military base.
Trump's victory in the 2016 presidential election shocked British diplomats in Washington and relations between May, a vicar's daughter, and the president have been strained at times.
They said that the performers will also be marching with a fetish group, as Fetish Week London is running from July 8 to 15.
The monarch regularly meets Presidents of the United States and their spouses at Windsor Castle, including Barack and Michelle Obama, George W. Bush and Laura Bush, and Ronald and Nancy Reagan.
The trip comes amid scheduled protests throughout central London where demonstrators plan to fly a huge balloon depicting Trump as a baby.
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On Thursday, Trump will travel to Blenheim Palace, the 18th-century mansion where Britain's World War Two leader Winston Churchill was born and spent most of his childhood.
She listed Mr Trump's immigration policies, bans on some people entering the United States, his foreign policies, and lack of support for taking action on climate change as having affects across the globe.
Among the crowd of protesters outside American man Martin Williams, who works at Oxford University, called Mr Trump a dictator.
Some British citizens are even more distressed about Trump than they are about the U.K.'s own feverish political turmoil.
"She is a tremendous woman", Trump said of Elizabeth in an interview Thursday with The Sun tabloid, noting that his Scottish-born mother "loved" the queen. "I think they agree with me on immigration".
Trump is on a "working visit" rather than a full state occasion.
Add in the embarrassment if they happen to be the leader of the free world.
Adding that it seemed as if the United Kingdom was "getting at least partially involved back with the European Union".
Mr Trump had joked earlier this week that his meeting with Vladimir Putin in the Finnish capital Helsinki on Monday "may be the easiest" part of his European trip.
The trip includes meetings with Prime Minister Theresa May, who has described the U.S. as Britain's strongest ally, and is determined to secure a trade deal after the country acts on Brexit and leaves the European Union in March 2019.
